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Desensitization at the receptor level is usually referred to as uncoupling, and is explained by GRK-mediated receptor phosphorylation and subsequent binding of arrestins in steric competition with G proteins to the cavity formed on the cytoplasmic side of activated receptors [6, 7]

& Beniac, V

If you are looking at the above list and thinking that sounds a little bit like you, then you might want to try and increase you glutathione levels and there are two distinct ways you can go about it